Each plastic ampoule (10 ml) contains:

 Citicoline (formed citicoline sodium):.....................100mg

Oral solution

- Conscious disorders caused by injury or after brain surgery

- Support recovery of movement with patients with hemiplegia after stroke

- Parkinson's disease has a severe tremor

- Old age dementia (including Alzheimer's disease)

PHARMACODYNEMIC:

Citicoline stimulates the biosynthesis of structural phospholipids of the neuronal membrane as it is demonstrated in the magnetic resonance spectroscopy studies. Citicoline, through its action, improves the function of the membrane mechanisms, such as the functioning of the ionic exchange pumps and receptors inserted in the latter, the modulation of which is indispensable in the neurotransmission.

Citicoline due to its membrane stabilizing activity has properties which favour brain oedema reabsorption.

Experimental studies have shown that citicoline inhibits the activation of some phospholipases (A1, A2, C and D), reducing the formation of free radicals, avoiding the destruction of membranous systems and preserving antioxidant defence systems as glutathione.

Citicoline preserves the neuronal energetic reserve, inhibits apoptosis and stimulates acetylcholine synthesis.

It has been experimentally shown that citicoline also exerts a prophylactic neuroprotective effect in focal brain ischemic models.

Clinical trials have shown that citicoline significantly increases the functional evolution of patients with acute ischemic cerebrovascular accident, coinciding with a lower growth of the brain ischemic injury in neuroimaging tests.

In patients with craniocerebral traumatisms, citicoline speeds up their recuperation and reduces duration and intensity of the post-concussional syndrome.

Citicoline improves the level of attention and consciousness and acts favourably over amnesia and cognitive and neurological disorders associated to brain ischemia.

DOSAGE AND USAGE

            Dose

Acute brain disease recovery phase
Adults: 2 ampoules 10 ml x 3 times/day

Children: 1 ampoules 10 ml x 2-3 times/day

Chronic brain disease
Use oral dose as recovery phase

Elderly: No need to adjust the dose.
Method of administration

It may be taken directly or dissolved in half glass of water (120 ml)