Nebulization — Face Mask, Mouthpiece, Tracheostomy:

When nebulized into a face mask, mouthpiece, or tracheostomy, 2 to 20 mL of the 10% solution may be given every 2 to 6 hours; the recommended dose for most patients is 6 to 10 mL of the 10% solution three to four times a day.

Nebulization — Tent, Croupette:

In special circumstances it may be necessary to nebulize into a tent or Croupette, and this method of use must be individualized to take into account the available equipment and the patient’s particular needs. This form of administration requires very large volumes of the solution, occasionally as much as 300 mL during a single treatment period.

If a tent or Croupette must be used, the recommended dose is the volume of acetylcysteine that will maintain a very heavy mist in the tent or Croupette for the desired period. Administration for intermittent or continuous prolonged periods, including overnight, may be desirable.

Direct Instillation:

When used by direct instillation, 1 to 2 mL of a 10% solution may be given as often as every hour.

When used for the routine nursing care of patients with tracheostomy, 1 to 2 mL of a 10% solution may be given every 1 to 4 hours by instillation into the tracheostomy.

Acetylcysteine may be introduced directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea.

Acetylcysteine may also be given through a percutaneous intratracheal catheter. Two to 4 mL of the 10% solution every 1 to 4 hours may then be given by a syringe attached to the catheter.

Diagnostic Bronchograms:

For diagnostic bronchial studies, 2 or 3 administrations of 2 to 4 mL of the 10% solution should be given by nebulization or by instillation intratracheally, prior to the procedure.

If only a portion of the solution in a vial is used, store the remainder in a refrigerator and use for inhalation only within 96 hours.

ZENACE

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