Progesterone 400 mg/suppository

Suppository

1) Treatment of premenstrual syndrome, including premenstrual tension and depression.
2) Treatment of puerperal depression.
3) Luteal phase support as part of an Assisted Reproductive Technology (ART) treatment for women.) 
4) Prevention of preterm birth in singleton pregnancies at risk due to; 
Shortened cervix (midtrimester sonographic cervix ≤25mm).  
and/or  
Where there is a history of spontaneous preterm birth.

For the treatment of premenstrual syndrome and puerperal depression:
200mg daily to 400mg twice a day, by vaginal or rectal insertion. For premenstrual syndrome commence treatment on day 14 of menstrual cycle and continue treatment until onset of menstruation. If symptoms are present at ovulation commence treatment on day 12.
For luteal phase support as part of an ART treatment:
400 mg administered vaginally twice a day starting at oocyte retrieval. The administration of Cyclogest should be continued for 38 days, if pregnancy has been confirmed.
Prevention of Preterm Birth 
The dosage of progesterone for prevention of preterm birth is 200 mg daily (at night). Treatment can be initiated during the second trimester (16-24 weeks gestation) and is to be continued to the end of the 36th week of gestation or until delivery. 
Other intravaginal therapies should not be used while progesterone pessary treatment is being undertaken.  
Patient Instructions:  
The pessary should be removed from its wrapper and inserted deep into the vagina, while either in a squatting position or lying on back or side.  If a daily dose is being administered then a preferable time of dosing is at night before retiring.  
Missed dose:  
A missed dose should be administered as soon as remembered, unless the missed dose is noticed at the day of the next dose.  In the latter case the missed dose should be omitted and the regular dosing regimen continued.