Hydroxocobalamin 5mg/ml

Solution for injection

Blood diseases:
- Idiopathic anemia or gastrectomy. 
- Spru's disease, diarrhea and other diseases of vitamin B12 deficiency due to poor absorption. 
- Absorption decreases after partial gastric bypass and gastrointestinal distress syndrome as well as rare cases of pregnancy-induced anemia. 
- Support treatment with aminosalicylate because it reduces the absorption of B12.

Addisonian pernicious anaemia and other macrocytic anaemias without neurological involvement:
Initially:    250 micrograms to 1000 micrograms intramuscularly on alternate days for one or two weeks then 250 micrograms weekly until blood count is normal.
Maintenance:    1000 micrograms every two or three months.
Addisonian pernicious anaemia and other macrocytic anaemias with neurological involvement:
Initially:    1000 micrograms on alternate days as long as improvement continues.
Maintenance:    1000 micrograms every two months.
Prophylaxis of macrocytic anaemias associated with vitamin B12 deficiency resulting from gastrectomy, ileal resection, certain ma/absorption states and vegetarianism: 1000 micrograms every two or three months.
Tobacco amblyopia and Leber's optic atrophy:
Initially:    1000 micrograms daily by intramuscular injection for two weeks then twice weekly as long as improvement is maintained.
Maintenance:    1000 micrograms every three months or as required.