Trimethoprim 16 mg/ml
Sulfamethoxazole 80 mg/ml

Concentrated solution for infusion

Cotrime-BFS is indicated in children aged 12 years and under (>6 weeks to <12 years old); children over 12 years old (>12 to < 18 years old) and adults (>18 years old) for the treatment of the following infections when owing to sensitive organisms:
• Acute uncomplicated urinary tract infection: It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than a combination such as Cotrime-BFS
• Treatment and prevention of Pneumocystis jirovecii pneumonitis or “PJP”.
• Treatment and prophylaxis of toxoplasmosis.
• Treatment of nocardiosis.
• In general, the indications for the use of Cotrime-BFS are the same as those for oral presentations.
Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Posology
The dosage of Cotrime-BFS should be adjusted to the need of the
individual.
Dosage schedules: The dose delivered to the patient varies depending onthe nebulising equipment used. The nebulisation time and the dose delivered is dependent on flow rate, volume of nebuliser chamber and fill volume. An air-flow rate of 6 - 8 litres per minute through the device should be employed. A suitable fill volume for most nebulisers is 2 - 4 ml.
The dosage of Cotrime-BFS should be adjusted to the need of the
individual. The dose should be reduced to the minimum needed to maintain good asthma control. The highest dose (2 mg per day) for children under 12 years should only be considered in children with severe asthma and during limited periods.

Bronchial asthma
Initiation of therapy
When treatment is started, during periods of severe asthma and while
reducing or discontinuing oral glucocorticosteroids, the recommended dose of Cotrime-BFS is:
Adults (including the elderly): Usually 1 – 2 mg twice daily. In very severe cases the dosage may be further increased.
Paediatric population
Children 12 years and older: Dosage as for adults.
Children 3 months to 12 years: 0.5 – 1 mg twice daily.
Maintenance
The maintenance dose should be individualised and be the lowest dose which keeps the patient symptom-free.
Adults (including the elderly and children 12 years and older): 0.5 - 1 mg twice daily.
Paediatric population
Children 3 months to 12 years: 0.25 - 0.5 mg twice daily.